PEBC Evaluating Exam prep, PEBC Qualifying Exam prep, PEBC OSCE prep, PEBC Technician Exams prep, Misbah Classes-Pharmacy Prep

Chapter 83 Skin, Soft tissue and Acute Osteomyelitis Q&A (1 of 29) Sample Questions

1. A patient is confirmed to have osteomyelitis. Doctor plans on starting Vancomycin orally for the patient. Which of the following is true?

A. Vancomycin is the best if given orally.
B. Oral vancomycin is not absorbed.
C. It is not the drug of choice against MRSA osteomyelitis.
D. None of the above.

Answer

Ans: B

Tips: Oral vancomycin is only used for P. colitis treatment. Otherwise, in all other infections, Vancomycin is used injection.
Absorption: Oral vancomycin is poorly absorbed from the GI tract. Intramuscular absorption is erratic. Intraperitoneal administration results in approximately 38% systemic absorption.
Distribution: The volume of distribution of vancomycin is 0.4–1 L/kg and the α-distribution phase ranges from 30 minutes to 1 hour. Vancomycin is 50–55% protein bound. The drug distributes widely into body tissue and fluids including pericardial, pleural, ascitic and synovial fluid. Low and variable vancomycin concentrations are obtained in CSF; however, inflammation increases CSF penetration and concentrations may be higher here in patients with meningitis. Penetration into skin and lung tissue has been found to be variable

WELCOME TO PHARMACY PREP